Where you absolutely refuse to go the cheap way.
For me its deodorant. Everything else I’ve found but my chosen brand fails me.
Toilet paper
Everything that is under you. Shoes, mattress, bike, car, desk chair etc.
Cheaping out on the above will cost you more in hospital and physical therapy bills.
PC power supply.
Never, ever skimp on a power supply. Get one from a reputable brand and with a rating above what you may actually need.
A failed PSU can in principle wreak havoc on any other components in the system, many of which are far more expensive than the PSU itself.
I totally get why you might not but for me, quality underwear has been a great purchase. They last longer, breath better, stay put, and synthetic ones are washable in a sink in a pinch when traveling(I mean they all are but these dry really quick)
Coffee beans for sure (gotta love freshly roasted specialty beans!), but also vegetables (organic & local are the best). Oh, and also headphones, for sure.
To me these are all totally worth it because the jump in quality is very noticeable. After a certain price point, though, the law of diminishing returns kicks in hard