If you want comfortable, you don’t get a mouse. You get a trackball that fits your hands well. I use an Elecom Huge and I love it. Especially having 7680 pixels of horizontal resolution (1080p side monitors and 4k center screen). Going from edge to edge with a single flick is so damn satisfying.
As someone who dailies a trackball, mouse, and trackpad: it depends on the setup. Trackpad is nice for when I’m on my laptop with just one screen. Mouse is nice with two high resolution displays and gaming. And at work I exclusively use a trackball across a triple monitor setup.
Trackpads are finicky. They need to have good hardware and software support, and as far as I’m aware, Apple is seemingly the only vendor capable of both. So naturally I only ever prefer it on my test macs for work.
One of my Lenovos, I’d almost prefer to rub the g-spot because of the clunky trackpad