I hate hate hate this so much. This is precisely the kind of smug, reductionist, dunning-kruger, every-problem-is-a-nail-and-programming-is-my-hammer type of shit that fuels my hatred of not only TESCREAL but pretty much everyone I meet in STEM.
I wonder how much of the coder mindset is behind the anarchist diy chemistry biohacking people (which seems to distress people who have actual experience in chemistry).
When I think of diy bio hacking I think of “The Thought Emporium”, thankfully he knows his stuff is not suitable for the public.
these people are full of shit. sofosbuvir contains single fluorine atom in such a place that its introduction requires either hydrogen fluoride (also as NEt3.3HF) or DAST (or other very friendly reagents like Xtalfluor-E) and even then, synthesis sucks balls as in has low-to-medium yield (15-50%) and requires extensive purification. you do not, under any circumstances, fuck around with hydrogen fluoride in your garage
relevant patent https://worldwide.espacenet.com/patent/search/family/051842422/publication/WO2016066283A1?q=pn%3DWO2016066283 first few pages for literature review, around 97-102 for procedures. these sub-50% yields are already heavily optimized
I honestly feel really bad when I see fairly respected leftists and journalists celebrate Four Thieves as something that could make a big difference for folks who are paying way too much for medicine (which is all of us) and enable a mutual support network of hobby chemists saving lives.
and then I look at it and that’s not what I see at all — it’s just a fucking cosplay anarchist (complete with cheap camo pants) with the type of opsec that gets the people around them arrested and an understanding of chemistry that will get people killed. and that fucking sucks! the part of me that’s susceptible to a dream like this thinks a 3D printer for medicine (per the marketing) is a great idea!
every other part of me is horrified. 3D printers barely fucking work and that’s our reliability target for fucking organic chemistry, a branch of science where it’s so easy (and sometimes necessary for a synthesis, as you pointed out) to produce chemical byproducts that give you fucking horrifying cancer if you’re lucky? and then the fucker just forgets or doesn’t know about yield and purification? this fucker calls his output “street drugs” and expects you to fucking bareback them without an appropriate validation to make sure you haven’t synthesized fucking poison in your little tin-foil-and-tape reaction vessel? and he sure as fuck isn’t giving test catalysts out with the pills he keeps throwing into crowds
one thing I’ve noticed from this most recent article is they forked some MIT designs for their synthesis discovery software and their chemical reactor. I’m not a chemist, any chemistry knowledge above was gleaned from YouTube and probably isn’t correct (let me know if I was way off), so I wanna know — is there anything at all to that for any drug, or is the idea as a whole just fucking terrible? I’m leaning towards the latter, but like I mentioned, I’m susceptible to this kind of dream.
I have found a way to solve world hunger with a fork bomb
I also had some extremely cringeworthy and not-even-wrong opinions 23 years ago, but at least I was 3yo then.
can’t decide if it’s soothing or infuriating to learn/realize that, despite insane wealth causing him to get billionairebrain, he’s also always been quite the dim fuckwit
So as a programmer I was a little offended but then I remembered I’m not good so I’ll let it slide.
Yea a plane hijacking is totally like a buffer overflow.
Bleeding is also a bit like a buffer overflow, since blood goes in a place it’s not supposed to. Hurricanes are another example of a buffer overflow. Accidentally wearing a shirt inside out? Buffer overflow. Unskippable ads are buffer overflow. War is buffer overflow. I had my buffer overflown by some guy claiming to be a wallet inspector. Aliens are a type of buffer overflow. I sometimes have buffer overflow with my girlfriend. Buffer overflow was an inside job. I put too much shine paste in my polishing machine and you better believe that was a buffer overflow.
When a train crashes into a station building, that’s not a buffer overflow, though. That’s a buffer overrun.
You can totally hack a plane using a buffer overflow. C airlines don’t check how many tickets they sell on a single flight. Usually if you overbook a flight, they will simply reallocate some of their buffer into business class. However, if you buy a bunch of tickets to one flight at once, you can craft a scenario where you overwrite the pilot.
Nope, actually this used to work but the genius computer scientists at Boeing put the cockpit in a random place around the cabin, thwarting most pilot overwrite attacks.
