24 points

Neither the article nor the original paper spell this out explicitly, but I assume the link to depression has as much to do with the way the salience network expansion comes at the expense of other networks (like the cingulo-opercular and frontoparietal) as with the salience network itself. Like, you have a heightened awareness of what’s happening around you, but a reduced sense of agency or ability to react.

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16 points

Like, you have a heightened awareness of what’s happening around you, but a reduced sense of agency or ability to react.

Holy shit this is exactly how I feel a lot of the time. Your sense of agency refers to your percieved ability to alter the outcome of an event, yes?

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8 points

Yeah, pretty much.

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5 points

Well fuck.

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3 points

Diego Pizzagalli

What a name.

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1 point

So is the brain rewiring at some point? Or does it get damaged? Or is it prewired and then turns on at some point? Depression is a disease, but people usually aren’t born depressed.

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4 points

The paper says it’s a persistent part of the brain’s development. It’s not a symptom of depression, it’s a heritable trait found in people prone to depression.

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