https://knowyourmeme.com/memes/loss

TL;DR: Somebody made a really weird episode of a web comic and the configuration of the figures in the panel has become a meme named “Loss” after the name of that episode. Pic related:

The joke here is that evolution gave you pattern recognition to avoid predators, but now you are using it for useless things like recognising this comic is spatially organised in the same way the Loss comic is.