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I have always been prone to having horrible hangovers, even in my twenties. Dihydromyricetin has saved my almost forty year old ass from the worst of them by now.
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3292407/
It is used to lessen withdrawal symptoms when treating alcoholics in some parts of the world.
Taken half an hour before starting and at the end of the evening strongly reduces the worst hangover effects.
No miracle cure, but it lessens the most severe hangover symptoms.