They all have there pluses. Currently I really like Heroic.
Lutris has community scripts to install.
Can be nice for the different versions of games out there, not just gog.
Bottles is cool because it really focuses on you having complete control is wine.
Heroic is great because you can log into gog through it and install the games. Somewhat like Steam. Just noticed you can have Heroic link installed games to Steam
I have found that lutris scripts are often so out of date that they often break as much as they solve.
Battle.net games had this problem for a long time tested on 2 different systems. Bottles worked perfectly by default.