I’m not talking about targeted harassment specifically, I mean dozens of accounts leaving bigoted remarks on any post about queer subjects that gets traction (more than a few thousand likes). Melon certainly made the problem worse on Twitter, but there’s a reason prior to that they had an entire department dedicated to dealing with that shit: plenty of people see no problem with it, and it makes social media a nightmare for queer people.
If you don’t have a strong trust and safety team, then you need blocking tools that do the heavy lifting. And having to block 50k bigots manually is why I left Twitter. As long as Mastodon doesn’t have anything that can compete with block lists, it’s going to struggle to attract people who need those features.