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17 points

I’m currently writing a small literature review on tgf-b and SMAD signalling in cancer for uni rn

And I’m really confused why this one paper’s talking about how miR-520h induces the tgf-b/smad7 pathway but also binds to and suppresses smad7

Like why on earth is it activating the tgf-b/smad7 pathway, a pathway that stops stuff like the epithelial mesenchynal transition, if it’s just going to bind to smad7 anyway???

Worst thing is, I can’t find any other papers on why this actually happens

I swear I’m just dumb at times ;-;

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17 points

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1 point

I’ll take two scoops

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8 points

Ah, yes. Of course. I understand your frustration entirely because of my deep understanding of the specific situation.

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5 points

Would a list of tools and search engines be helpful?

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1 point

That would be very helpful 🥴

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2 points

Sorry, better late than never. Will dm you. Others are welcome too.

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4 points

Cell signalling pathways was the worst part of microbial genetics for me. Luckily I don’t have to deal with that anymore as my day to day is digital PCR and NGS.

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