What’s the grand scheme of things mean to you? If we average it out over 40 years? How does nuclear even fit in when solar and wind are cheaper? Nuclear plants don’t provide on demand energy to fill in the gaps, they provide energy constantly.
The only reason it works for microsoft is because they plan to use all that energy consistently. But besides that why should we trust a for-profit company to do anything safely in the first place? Do we have a long history of companies being regulated well or self-regulating well?
The nuclear industry is heavily regulated by the government via the NRC, but they impose even stricter regulations upon themselves. Solar and wind are cheaper, but they are less reliable. A grid comprised of a mix of solar and wind, bolstered by nuclear is the most effective and least environmentally harmful option that we currently have.