I’d argue that we can predict ecosystem effects. In America we annihilated malaria hot spots with DDT. Didn’t seem to crash any ecosystems.
Though it didn’t “crash” any ecosystems, DDT still accumulates in the environment, where it remains for a long time and causes ongoing harm to insects and the animals that prey on them. Though the most problematic use of DDT by far is in agriculture, its use against mosquitoes isn’t exactly without issue. Not to mention, mosquito populations can become resistant to DDT, requiring more of it to achieve the same effect.
The whole point is that DDT caused a mosquito crash and nothing bad happened. If we can crash mosquitoes without DDT, it would be better for everyone.
I wouldn’t say that nothing bad happened. America – particularly urban areas where anti-mosquito measures have been implemented – has been dealing with declines of important populations of birds and insects, and we don’t fully understand the exact causes. Which is to say, we don’t know what role mosquito population reduction has played in this. We have vaccines against mosquito-borne illnesseses, which I believe are preferable to eradicating a species and the potentially devastating consequences we could encounter.
Didn’t seem to doesn’t necessarily mean it didn’t happen, it can be difficult to quantify. Most people don’t notice a lot of the constant large scale ecological devastation that does happen.
The real concern is that even if it was fine in one location, that can’t reliably be assumed to be the case for other ecosystems. This issue is really complicated, we’ve acted hastily in the past and done some insane lasting damage so I’d say it’s best to be careful.
All that said, even if I’m vegan and this whole thing makes me extremely uncomfortable, working to eradicate malaria is objectively good.