Can be from any kind of media.
For me it’s Margot from The Magicians (which is interesting because in the books she is anything but) and Jesse Faden from Control.
Literally the first name that popped into my head when I saw the question. There are plenty of other good choices, but she has to be near the top of any list.
Incidentally… am I having federation issues? This is the only comment I see mentioning Ripley. I see 11 comments currently…