As a user of a small TKL keyboard, I can say from my own experience having a small keyboard makes it easy and less strenuous to switch between the mouse and keyboard since they are so close together. I also find I don’t really miss the extra keys, I can do my job just fine if not better without them, because of the added benefit of moving fast.
I currently do a data heavy job and almost never use my keypad. Just can’t come to terms with letting it go. 96% might be the step that gets me to ditch the numpad!