I forget where I heard this but someone mentioned that a 4-dimensional being could mirror you. Doesn’t sound so bad until you realize your amino acids & stuff would all be the opposite chirality, which means you could no longer process food.
There’s a great YA book about this: https://en.wikipedia.org/wiki/The_Boy_Who_Reversed_Himself?wprov=sfla1
Mass Effect has a similar idea. There are species that eat levo foods and ones that eat dextro foods.
Heh, eating isn’t the only time they have to worry about protein absorption.
This, the mirroring part, also happens in an Arthur C. Clarke short story: https://en.wikipedia.org/wiki/Technical_Error